| M. Forte | RB |  Wessel,  Bronchtein,  Banys,  Ballard | 2010–2015 | 91 | 1102.0 | 12.1 |
| J. Cutler | QB | Wessel,  Norberg,  Valenzuela,  Foote, Banys, Bronchtein,  Wright,  Baumann,  Waxman,  Freundlich | 2010–2016 | 68 | 808.6 | 11.9 |
| A. Jeffery | WR | Foote, Wright,  Rath, Valenzuela, Baumann | 2012–2016 | 66 | 553.3 | 8.4 |
| A. Robinson | WR |  Sohl | 2018–2020 | 47 | 516.8 | 11.0 |
| D. Moore | WR | Wright, Foote,  Becker-Parton | 2022–2025 | 49 | 503.1 | 10.3 |
| J. Howard | RB | Wright, Valenzuela | 2016–2018 | 44 | 496.7 | 11.3 |
| B. Marshall | WR | Ballard, Wright, Norberg | 2012–2014 | 43 | 482.7 | 11.2 |
| T. Cohen | RB | Valenzuela, Foote, Baumann, Norberg, Becker-Parton | 2017–2020 | 46 | 369.0 | 8.0 |
| R. Gould | K | Bronchtein, Norberg, Foote, Ballard,  Wood | 2011–2015 | 44 | 365.0 | 8.3 |
| D. Swift | RB |  Faust, Banys | 2023–2025 | 32 | 362.9 | 11.3 |
| D. Montgomery | RB | Freundlich, Sohl | 2019–2020 | 31 | 326.0 | 10.5 |
| J. Fields | QB | Foote, Baumann | 2022 | 16 | 275.1 | 17.2 |
| C. Williams | RB | Foote | 2025 | 16 | 273.6 | 17.1 |
| M. Bennett | TE | Banys, Freundlich, Bronchtein | 2013–2015 | 42 | 268.7 | 6.4 |
| K. Allen | WR | Wright | 2023 | 16 | 224.9 | 14.1 |
| K. Herbert | RB |  P. Waxman, Valenzuela, Foote | 2022–2023 | 33 | 197.7 | 6.0 |
| D'Andre Swift | RB |  Kassel | 2024 | 17 | 181.0 | 10.6 |
| DJ Moore | WR | P. Waxman | 2024 | 17 | 171.5 | 10.1 |
| David Montgomery | RB | Ballard | 2021 | 16 | 155.3 | 9.7 |
| Keenan Allen | WR | Faust | 2024 | 17 | 147.4 | 8.7 |
| Caleb Williams | QB | Freundlich, Becker-Parton, Waxman | 2024 | 12 | 134.2 | 11.2 |
| M. Trubisky | QB | Banys | 2018 | 7 | 133.6 | 19.1 |
| J. Langford | RB | Wright, Becker-Parton, Freundlich | 2015–2016 | 19 | 133.0 | 7.0 |
| R. Odunze | WR | Foote | 2025 | 16 | 124.1 | 7.8 |
| D. Foreman | RB | Valenzuela | 2022 | 11 | 118.0 | 10.7 |
| T. Burton | TE | Freundlich, Becker-Parton | 2018 | 15 | 111.1 | 7.4 |
| Darnell Mooney | WR | Valenzuela, Kassel, Becker-Parton, P. Waxman, Baumann | 2021 | 12 | 106.5 | 8.9 |
| A. Miller | WR | Banys, Wright, Foote | 2018–2020 | 14 | 98.9 | 7.1 |
| C. Santos | K | Freundlich, Valenzuela, Baumann, Becker-Parton | 2017–2025 | 12 | 98.0 | 8.2 |
| K. Monangai | RB | Valenzuela, Faust, Kassel | 2025 | 10 | 92.7 | 9.3 |
| D. Hester | WR | Norberg, Wood | 2010–2011 | 23 | 89.5 | 3.9 |
| D. Mooney | WR | Ballard | 2022 | 12 | 81.5 | 6.8 |
| Rome Odunze | WR | Bronchtein, Wright, Freundlich | 2024 | 13 | 80.1 | 6.2 |
| Z. Miller | TE | Wright, Ballard | 2015–2016 | 10 | 78.7 | 7.9 |
| J. Graham | TE | Banys, Bronchtein | 2020 | 12 | 73.5 | 6.1 |
| C. Meredith | WR | Valenzuela, Becker-Parton | 2016 | 9 | 71.5 | 7.9 |
| M. Bush | RB | Norberg, Bronchtein, Wood | 2012–2013 | 15 | 59.3 | 4.0 |
| G. Everett | TE | Bronchtein, Ballard | 2023 | 12 | 58.7 | 4.9 |
| C. Claypool | WR | Kassel, Freundlich | 2022 | 10 | 50.7 | 5.1 |
| E. Pineiro | K | Sohl | 2019 | 10 | 48.0 | 4.8 |
| C. Loveland | TE | Valenzuela, Freundlich | 2025 | 5 | 45.5 | 9.1 |
| L. Burden | WR | Valenzuela | 2025 | 3 | 44.2 | 14.7 |
| Khalil Herbert | RB | Bronchtein | 2021 | 6 | 43.1 | 7.2 |
| C. Parkey | K | Wright, Norberg | 2018 | 7 | 42.0 | 6.0 |
| G. Olsen | TE | Becker-Parton | 2010 | 10 | 37.6 | 3.8 |
| Cairo Santos | K | Ballard, Freundlich, Bronchtein | 2021–2024 | 6 | 32.0 | 5.3 |
| R. Johnson | RB | Waxman, Valenzuela | 2023 | 6 | 27.6 | 4.6 |
| T. Gabriel | WR | Becker-Parton, Freundlich | 2018–2019 | 5 | 25.7 | 5.1 |
| B. Hoyer | QB | Freundlich | 2016 | 1 | 23.8 | 23.8 |
| Roschon Johnson | RB | Kassel, P. Waxman | 2024 | 3 | 23.1 | 7.7 |
| R. Tonyan | TE | Kassel, Bronchtein, Freundlich | 2022 | 5 | 23.0 | 4.6 |
| J. McCown | QB | Bronchtein | 2013 | 3 | 22.7 | 7.6 |
| N. Foles | QB | Becker-Parton | 2020 | 2 | 21.5 | 10.7 |
| K. White | WR | Waxman, Freundlich | 2016–2017 | 4 | 15.0 | 3.8 |
| Justin Fields | QB | Faust | 2021 | 3 | 13.1 | 4.4 |
| D. Aromashodu | WR | Becker-Parton | 2010 | 3 | 7.1 | 2.4 |
| R. Williams | RB | Wood | 2011 | 4 | 7.0 | 1.8 |
| E. Royal | WR | Waxman, Norberg, Freundlich | 2015–2016 | 3 | 5.2 | 1.7 |
| T. Homer | RB | Valenzuela | 2022 | 1 | 4.4 | 4.4 |
| M. Barber | RB | Bronchtein | 2011 | 2 | 3.3 | 1.7 |
| M. Nugent | K | Freundlich | 2017 | 1 | 1.0 | 1.0 |
| S. Hurd | WR | Freundlich | 2011 | 1 | 0.0 | 0.0 |
| E. Bennett | WR | Banys | 2013 | 1 | 0.0 | 0.0 |