| P. Rivers | QB |  Ballard,  Banys,  Bronchtein,  Freundlich,  Valenzuela,  Wright,  Waxman,  Norberg | 2010–2019 | 146 | 2175.9 | 14.9 |
| K. Allen | WR | Valenzuela,  Baumann, Freundlich, Wright,  Becker-Parton, Waxman,  Sohl, Ballard | 2013–2025 | 128 | 1261.9 | 9.9 |
| J. Herbert | QB | Baumann, Freundlich, Waxman, Banys | 2020–2025 | 57 | 920.0 | 16.1 |
| M. Gordon | RB | Baumann, Banys, Ballard, Becker-Parton | 2015–2019 | 75 | 871.6 | 11.6 |
| A. Ekeler | RB | Freundlich, Sohl, Bronchtein, Baumann | 2017–2022 | 65 | 808.8 | 12.4 |
| A. Gates | TE | Ballard,  Wood, Becker-Parton, Valenzuela,  Foote | 2010–2017 | 105 | 693.9 | 6.6 |
| R. Mathews | RB | Freundlich, Becker-Parton, Foote, Banys | 2010–2014 | 75 | 556.6 | 7.4 |
| Justin Herbert | QB | Sohl, Foote, Freundlich | 2021–2024 | 25 | 460.6 | 18.4 |
| M. Williams | WR | Banys, Valenzuela, Baumann, Ballard, Foote,  P. Waxman | 2017–2022 | 59 | 454.7 | 7.7 |
| M. Floyd | WR | Becker-Parton, Foote, Wright, Baumann, Freundlich, Ballard, Norberg | 2010–2015 | 54 | 347.6 | 6.4 |
| H. Henry | TE | Foote, Bronchtein, Valenzuela, Sohl | 2016–2020 | 46 | 339.2 | 7.4 |
| D. Woodhead | WR | Wright, Valenzuela, Becker-Parton, Waxman, Norberg | 2013–2016 | 35 | 304.6 | 8.7 |
| Austin Ekeler | RB | Bronchtein | 2021 | 17 | 282.4 | 16.6 |
| C. Dicker | K | Valenzuela, Ballard, P. Waxman | 2022–2025 | 27 | 230.0 | 8.5 |
| M. Tolbert | RB | Bronchtein, Foote,  Wessel, Freundlich, Banys | 2010–2011 | 23 | 198.0 | 8.6 |
| Keenan Allen | WR | P. Waxman | 2021 | 17 | 196.6 | 11.6 |
| V. Jackson | WR | Ballard, Banys | 2010–2011 | 27 | 195.6 | 7.2 |
| Mike Williams | WR | P. Waxman,  Kassel | 2021–2024 | 18 | 186.2 | 10.3 |
| Ladd McConkey | WR | Bronchtein | 2024 | 17 | 185.9 | 10.9 |
| T. Williams | WR | Valenzuela, Wright, Becker-Parton | 2016–2018 | 22 | 174.5 | 7.9 |
| Najee Harris | RB | Becker-Parton | 2024 | 17 | 173.0 | 10.2 |
| J.K. Dobbins | RB | Waxman, Valenzuela | 2024 | 16 | 166.8 | 10.4 |
| T. Benjamin | WR |  Rath | 2016–2017 | 30 | 161.2 | 5.4 |
| G. Edwards | RB | Valenzuela, Foote | 2023 | 13 | 156.5 | 12.0 |
| N. Novak | K | Ballard, Foote, Becker-Parton, Valenzuela | 2011–2014 | 19 | 155.0 | 8.2 |
| J. Palmer | WR | Sohl, Kassel, Waxman | 2022–2023 | 20 | 154.3 | 7.7 |
| L. McConkey | WR | Baumann | 2025 | 17 | 147.9 | 8.7 |
| Q. Johnston | WR | Kassel, Valenzuela, Freundlich | 2023–2025 | 21 | 131.3 | 6.3 |
| Cameron Dicker | K | Bronchtein, Waxman | 2024 | 12 | 112.0 | 9.3 |
| Quentin Johnston | WR | Banys | 2024 | 16 | 109.1 | 6.8 |
| O. Hampton | RB | Banys | 2025 | 16 | 103.7 | 6.5 |
| K. Vidal | RB |  Faust | 2025 | 11 | 100.7 | 9.2 |
| J. Jackson | RB | Valenzuela | 2018–2020 | 12 | 97.4 | 8.1 |
| Gerald Everett | TE | Sohl | 2021 | 17 | 91.3 | 5.4 |
| L. Green | TE | Valenzuela, Foote, Rath | 2013–2015 | 21 | 87.6 | 4.2 |
| G. Everett | TE | Valenzuela, Banys | 2022 | 15 | 79.2 | 5.3 |
| D. Sproles | RB | Ballard | 2010 | 16 | 78.1 | 4.9 |
| E. Royal | WR | Valenzuela, Ballard, Norberg | 2013–2014 | 16 | 73.5 | 4.6 |
| Jared Cook | TE | Ballard, Becker-Parton, Faust | 2021 | 11 | 70.9 | 6.4 |
| J. Lambo | K | Waxman, Wright | 2015–2016 | 9 | 65.0 | 7.2 |
| Gus Edwards | RB | Sohl | 2024 | 16 | 60.3 | 3.8 |
| O. Gadsden | TE | Freundlich | 2025 | 10 | 57.8 | 5.8 |
| B. Oliver | RB | Wright, Foote, Freundlich | 2014–2017 | 13 | 55.0 | 4.2 |
| S. Johnson | WR | Banys, Wright | 2015 | 10 | 45.7 | 4.6 |
| Ezekiel Elliott | RB | Foote | 2024 | 16 | 45.4 | 2.8 |
| Dustin Hopkins | K | Becker-Parton | 2021 | 5 | 41.0 | 8.2 |
| Justin Jackson | RB | Freundlich, Wright | 2021 | 3 | 39.0 | 13.0 |
| M. Badgley | K | Wright, Waxman, Freundlich | 2018–2019 | 6 | 38.0 | 6.3 |
| R. Meachem | WR | Banys | 2012 | 6 | 30.9 | 5.1 |
| D. Alexander | WR | Valenzuela | 2012 | 4 | 30.5 | 7.6 |
| D. Hopkins | WR | Becker-Parton | 2022 | 4 | 26.0 | 6.5 |
| K. Ballage | RB | Freundlich | 2020 | 5 | 22.1 | 4.4 |
| D. Brown | RB | Wright | 2014 | 4 | 17.3 | 4.3 |
| Jalen Guyton | WR | Freundlich | 2021 | 1 | 16.2 | 16.2 |
| V. Brown | WR | Valenzuela, Wright | 2013 | 4 | 15.6 | 3.9 |
| P. Crayton | WR | Banys | 2010 | 2 | 12.8 | 6.4 |
| R. McMichael | TE | Ballard | 2010 | 6 | 11.5 | 1.9 |
| J. Dobbins | RB | Baumann | 2023 | 1 | 10.7 | 10.7 |
| N. Harris | RB | Foote | 2025 | 5 | 10.1 | 2.0 |
| Will Dissly | TE | Valenzuela | 2024 | 2 | 9.6 | 4.8 |
| T. Taylor | QB | Foote | 2020 | 4 | 9.0 | 2.3 |
| K. Farrow | RB | Wright | 2016 | 2 | 9.0 | 4.5 |
| L. Naanee | WR | Bronchtein, Ballard | 2010 | 8 | 6.9 | 0.9 |
| Kimani Vidal | RB | Valenzuela, Wright | 2024 | 3 | 6.8 | 2.3 |
| T. Harris | WR | Bronchtein | 2025 | 3 | 6.0 | 2.0 |
| H. Hurst | TE | Freundlich | 2023 | 2 | 5.1 | 2.6 |
| H. Haskins | RB | Valenzuela | 2025 | 1 | 2.8 | 2.8 |
| Tyler Conklin | TE | Waxman | 2024 | 1 | 1.5 | 1.5 |
| D. McCluster | WR | Becker-Parton | 2016 | 1 | 1.1 | 1.1 |
| I. Spiller | RB | Freundlich | 2022 | 1 | 1.0 | 1.0 |
| J. Battle | RB | Ballard | 2012 | 1 | 0.3 | 0.3 |
| D. Rosario | TE | Bronchtein | 2012 | 1 | -2.0 | -2.0 |