| D. Carr | QB | Valenzuela, Becker-Parton, Wright, Baumann, Freundlich | 2015–2020 | 52 | 778.7 | 15.0 |
| J. Jacobs | RB | Wright, Baumann, Sohl, Valenzuela | 2019–2022 | 46 | 646.0 | 14.0 |
| D. McFadden | RB | Ballard, Norberg, Valenzuela, Banys | 2010–2014 | 76 | 575.9 | 7.6 |
| D. Adams | WR | P. Waxman, Baumann | 2022–2023 | 33 | 456.4 | 13.8 |
| M. Crabtree | WR | Rath, Wright, Valenzuela | 2015–2017 | 46 | 413.4 | 9.0 |
| S. Janikowski | K | Freundlich, Banys, Baumann, Norberg, Foote, Wright, Waxman | 2010–2016 | 53 | 394.0 | 7.4 |
| D. Carlson | K | Becker-Parton, Banys, P. Waxman, Waxman, Sohl, Kassel | 2020–2025 | 49 | 383.0 | 7.8 |
| A. Cooper | WR | Waxman, Wright | 2015–2017 | 46 | 369.5 | 8.0 |
| L. Murray | RB | Valenzuela, Becker-Parton | 2014–2016 | 35 | 356.2 | 10.2 |
| D. Waller | TE | Banys, Foote | 2019–2020 | 30 | 338.0 | 11.3 |
| Davante Adams | WR | Becker-Parton | 2021 | 17 | 274.3 | 16.1 |
| J. Meyers | WR | Banys, Faust, Ballard | 2022–2023 | 29 | 271.2 | 9.4 |
| D. Moore | WR | Baumann, Wood, Foote | 2011–2013 | 39 | 237.0 | 6.1 |
| M. Bush | RB | Baumann, Demarkis | 2010–2011 | 26 | 236.1 | 9.1 |
| C. Palmer | QB | Baumann, Wright | 2011–2012 | 16 | 233.7 | 14.6 |
| J. Cook | TE | Ballard, Banys | 2017–2018 | 29 | 222.2 | 7.7 |
| A. Jeanty | RB | Valenzuela, Wright | 2025 | 17 | 206.7 | 12.2 |
| M. Lynch | RB | Bronchtein, Becker-Parton | 2017–2018 | 22 | 199.9 | 9.1 |
| Brock Bowers | TE | Becker-Parton | 2024 | 17 | 193.7 | 11.4 |
| Josh Jacobs | RB | Freundlich | 2021 | 17 | 177.6 | 10.4 |
| Hunter Renfrow | WR | Faust | 2021 | 14 | 163.0 | 11.6 |
| Geno Smith | QB | Ballard | 2024 | 13 | 160.0 | 12.3 |
| Derek Carr | QB | Faust, Kassel | 2021 | 12 | 142.2 | 11.8 |
| B. Bowers | TE | Becker-Parton | 2025 | 16 | 138.4 | 8.7 |
| A. Mattison | RB | Faust | 2023 | 16 | 114.9 | 7.2 |
| Jakobi Meyers | WR | Ballard | 2024 | 13 | 113.8 | 8.8 |
| J. Richard | RB | Wright, Banys, Becker-Parton, Bronchtein | 2016–2018 | 20 | 112.7 | 5.6 |
| T. Williams | WR | Norberg, Valenzuela | 2019 | 14 | 106.6 | 7.6 |
| Daniel Carlson | K | Banys, Baumann, Valenzuela | 2021 | 12 | 103.0 | 8.6 |
| Darren Waller | TE | Baumann | 2021 | 17 | 102.8 | 6.0 |
| J. Nelson | WR | Foote, Banys | 2018 | 15 | 101.1 | 6.7 |
| T. Pryor | QB | Becker-Parton, Valenzuela | 2013 | 7 | 90.6 | 12.9 |
| D. Martin | RB | Bronchtein | 2018 | 9 | 80.7 | 9.0 |
| J. Jones | WR | Freundlich, Baumann | 2014 | 14 | 74.3 | 5.3 |
| T. Tucker | WR | Bronchtein, P. Waxman | 2025 | 13 | 71.6 | 5.5 |
| R. Jennings | RB | Valenzuela, Freundlich | 2013 | 7 | 71.3 | 10.2 |
| D. Washington | RB | Valenzuela, Bronchtein, Freundlich, Wright | 2016–2019 | 12 | 67.6 | 5.6 |
| H. Renfrow | WR | Waxman, Norberg, Faust | 2020–2022 | 16 | 65.1 | 4.1 |
| Z. Miller | TE | Bronchtein, Freundlich, Banys | 2010 | 12 | 57.5 | 4.8 |
| J. Garoppolo | QB | Valenzuela, Becker-Parton | 2022 | 3 | 56.6 | 18.9 |
| N. Agholor | WR | Baumann | 2020 | 4 | 56.2 | 14.1 |
| Kenyan Drake | RB | Faust, P. Waxman | 2021 | 9 | 50.5 | 5.6 |
| M. Reece | RB | Freundlich | 2012 | 6 | 48.0 | 8.0 |
| D. Heyward-Bey | WR | Baumann, Ballard, Valenzuela, Foote | 2011–2012 | 15 | 44.9 | 3.0 |
| Raheem Mostert | RB | Faust, Wright, P. Waxman | 2024 | 10 | 44.2 | 4.4 |
| B. Myers | TE | Valenzuela | 2012 | 6 | 42.4 | 7.1 |
| A. Holmes | WR | Bronchtein | 2013–2014 | 6 | 38.0 | 6.3 |
| G. Smith | QB | Valenzuela, Bronchtein | 2025 | 3 | 35.5 | 11.8 |
| D. Carter | WR | Becker-Parton, Waxman, Ballard | 2022 | 6 | 30.4 | 5.1 |
| Peyton Barber | RB | Freundlich | 2021 | 3 | 24.9 | 8.3 |
| Brandon Bolden | RB | P. Waxman | 2021 | 4 | 22.8 | 5.7 |
| M. Rivera | TE | Ballard, Wright | 2014 | 3 | 21.4 | 7.1 |
| H. Ruggs | WR | Bronchtein, Freundlich | 2020 | 6 | 17.4 | 2.9 |
| S. Roberts | WR | Norberg | 2016 | 5 | 16.7 | 3.3 |
| Ameer Abdullah | RB | P. Waxman, Faust | 2024 | 2 | 16.5 | 8.3 |
| Bryan Edwards | WR | Bronchtein | 2021 | 2 | 15.6 | 7.8 |
| Zamir White | RB | P. Waxman | 2024 | 4 | 15.3 | 3.8 |
| L. Murphy | WR | Becker-Parton | 2010 | 4 | 14.2 | 3.6 |
| Z. White | RB | Wright | 2023 | 1 | 13.1 | 13.1 |
| G. Tavecchio | K | Bronchtein | 2017 | 2 | 13.0 | 6.5 |
| Foster Moreau | TE | Baumann, Wright | 2021 | 2 | 12.6 | 6.3 |
| D. Booker | RB | Becker-Parton | 2020 | 3 | 9.7 | 3.2 |
| F. Moreau | TE | Kassel | 2022 | 3 | 6.7 | 2.2 |
| D. Thornton | WR | Valenzuela | 2025 | 1 | 5.5 | 5.5 |
| M. Jones-Drew | RB | Banys, Ballard | 2014 | 7 | 4.9 | 0.7 |
| Sincere McCormick | RB | Valenzuela | 2024 | 1 | 3.5 | 3.5 |
| M. Gallup | WR | Faust | 2023 | 1 | 2.5 | 2.5 |
| B. Edwards | WR | Freundlich | 2020 | 1 | 1.4 | 1.4 |
| T. Jones | RB | Valenzuela | 2012 | 1 | 1.3 | 1.3 |
| J. Ford | WR | Baumann | 2011 | 1 | -0.1 | -0.1 |
| M. Schaub | QB | Wood | 2014 | 5 | -2.7 | -0.5 |