| B. Roethlisberger | QB | Lewis, Bronchtein, Freundlich, Norberg, Wright, Becker-Parton, Foote, Banys, Sohl | 2010–2020 | 142 | 2036.8 | 14.3 |
| A. Brown | WR | Freundlich, Becker-Parton, Bronchtein, Valenzuela, Rath, Wright | 2011–2018 | 117 | 1498.0 | 12.8 |
| L. Bell | RB | Becker-Parton, Wright, Ballard, Bronchtein, Valenzuela, Baumann | 2013–2018 | 80 | 979.7 | 12.2 |
| J. Smith-Schuster | WR | Banys, Norberg, Waxman, Baumann | 2017–2020 | 55 | 578.2 | 10.5 |
| J. Conner | RB | Wright, Foote, Banys | 2018–2020 | 45 | 508.5 | 11.3 |
| C. Boswell | K | Wright, Ballard, Waxman, Freundlich, Bronchtein, Becker-Parton, Faust, Sohl | 2016–2025 | 65 | 478.1 | 7.4 |
| M. Wallace | WR | Lewis, Norberg, Freundlich | 2010–2012 | 43 | 405.9 | 9.4 |
| J. Warren | RB | Freundlich, Bronchtein, Wright | 2022–2025 | 36 | 355.7 | 9.9 |
| N. Harris | RB | Banys, Waxman | 2022–2023 | 34 | 348.7 | 10.3 |
| R. Mendenhall | RB | Norberg, Foote, Ballard, Wright | 2010–2012 | 39 | 330.5 | 8.5 |
| G. Pickens | WR | Becker-Parton, Freundlich | 2022–2023 | 34 | 302.8 | 8.9 |
| D. Johnson | RB | Foote, Waxman, Ballard | 2019–2022 | 32 | 273.8 | 8.6 |
| Najee Harris | RB | Waxman | 2021 | 17 | 256.2 | 15.1 |
| D. Williams | RB | Bronchtein, Becker-Parton, Valenzuela | 2015–2016 | 28 | 250.0 | 8.9 |
| M. Bryant | K | Norberg, Baumann, Becker-Parton, Wright | 2014–2017 | 36 | 248.1 | 6.9 |
| H. Miller | TE | Lewis, Becker-Parton, Banys, Foote, Norberg | 2010–2015 | 44 | 217.1 | 4.9 |
| J. Fields | QB | Sohl | 2023 | 17 | 212.6 | 12.5 |
| Diontae Johnson | WR | Ballard | 2021 | 16 | 205.0 | 12.8 |
| R. Wilson | QB | Ballard | 2023 | 14 | 192.2 | 13.7 |
| Chris Boswell | K | P. Waxman, Faust, Ballard, Baumann | 2021–2024 | 18 | 178.0 | 9.9 |
| DK Metcalf | WR | Ballard | 2024 | 17 | 145.4 | 8.6 |
| D. Metcalf | WR | Faust | 2025 | 16 | 144.7 | 9.0 |
| P. Freiermuth | TE | Becker-Parton, P. Waxman, Banys, Wright | 2022–2023 | 23 | 142.4 | 6.2 |
| K. Gainwell | RB | Wright, Foote | 2025 | 12 | 128.1 | 10.7 |
| Pat Freiermuth | TE | Freundlich, Bronchtein, Baumann | 2021–2024 | 18 | 119.6 | 6.6 |
| Chase Claypool | WR | Faust | 2021 | 16 | 115.5 | 7.2 |
| E. Sanders | WR | Norberg | 2013 | 15 | 108.1 | 7.2 |
| C. Claypool | WR | Valenzuela | 2020 | 11 | 101.3 | 9.2 |
| J. Samuels | RB | Wright, Valenzuela, Freundlich, Bronchtein | 2018–2019 | 15 | 89.2 | 5.9 |
| Jaylen Warren | RB | Wright, Valenzuela | 2024 | 12 | 85.9 | 7.2 |
| H. Ward | WR | Norberg, Wood | 2010–2011 | 15 | 84.1 | 5.6 |
| A. Rodgers | QB | Freundlich, Wright | 2025 | 8 | 83.7 | 10.5 |
| V. McDonald | TE | Valenzuela, Norberg, Foote, Ballard, Freundlich | 2018–2019 | 15 | 72.5 | 4.8 |
| B. Tate | RB | Baumann | 2014 | 16 | 67.1 | 4.2 |
| M. Wheaton | WR | Wood, Bronchtein, Norberg, Baumann | 2014–2016 | 15 | 66.6 | 4.4 |
| E. Ebron | TE | Baumann, Becker-Parton | 2020 | 9 | 65.2 | 7.2 |
| J. Cotchery | WR | Ballard | 2013 | 9 | 55.4 | 6.2 |
| J. James | TE | Rath, Banys | 2016–2018 | 18 | 48.5 | 2.7 |
| B. Snell | RB | Becker-Parton | 2019–2020 | 5 | 44.2 | 8.8 |
| J. Dwyer | RB | Baumann, Wright | 2012 | 6 | 39.0 | 6.5 |
| A. Robinson | WR | Baumann, Kassel | 2022 | 7 | 35.4 | 5.1 |
| J. Smith | TE | Ballard, Freundlich, Bronchtein | 2025 | 6 | 34.4 | 5.7 |
| S. Suisham | K | Baumann, Waxman | 2014 | 4 | 29.0 | 7.3 |
| Trey Sermon | RB | Valenzuela, P. Waxman, Baumann | 2024 | 5 | 27.3 | 5.5 |
| L. Green | TE | Waxman | 2016 | 4 | 26.7 | 6.7 |
| E. Rogers | WR | Becker-Parton, Norberg | 2016 | 7 | 20.5 | 2.9 |
| I. Redman | RB | Valenzuela, Norberg | 2012 | 7 | 15.6 | 2.2 |
| D. Heyward-Bey | WR | Freundlich, Banys | 2015 | 4 | 13.4 | 3.4 |
| M. Vick | QB | Wright | 2015 | 1 | 12.3 | 12.3 |
| V. Jefferson | WR | Freundlich | 2023 | 1 | 4.4 | 4.4 |
| S. Coates | WR | Waxman | 2016 | 11 | 2.3 | 0.2 |
| D. Archer | RB | Banys | 2014 | 2 | 0.4 | 0.2 |
| C. Patterson | WR | Bronchtein | 2023 | 2 | 0.0 | 0.0 |
| K. Johnson | RB | Baumann, Faust | 2025 | 2 | -0.1 | 0.0 |